Scar Reducing Effect of the Silicone Gel Sheet with Verapamil in a Rabbit Model of Hypertrophic Scar.

RESULTS: The mean SEI, fibroblast counts, and capillary counts differed significantly among the five groups (P < 0.05). The median SEI was significantly lower in the SGS+2.5 mg verapamil/g group (Figure 1) than in the SGS group (Figure 2) (1.2 vs. 2.2). The median number of fibroblasts was significantly lower in the SGS+0.25 mg verapamil/g group than in the SGS group (172.5 vs. 243). The median number of capillary lumina was significantly higher in the untreated control group (29.5) whereas there was no significant difference between the SGS group and the SGS+0.25, SGS+2.5, and SGS+25 mg verapamil/g groups (28.5, 18, 20, and 18, respectively).